Primary hepatic anaplastic large-cell lymphoma diagnosed by fine-needle aspiration biopsy Academic Article uri icon


MeSH Major

  • HIV Seropositivity
  • Liver Neoplasms
  • Lymphoma, Large B-Cell, Diffuse


  • Anaplastic large-cell lymphoma (ALCL) presenting as primary hepatic lymphoma is exceedingly rare. Here, we report a case of primary hepatic ALCL, which was diagnosed by cytologic evaluation and concurrent immunohistochemical studies on the material obtained by fine-needle aspiration biopsy. The aspirate smears revealed many loosely dispersed, large atypical cells, some of them with kidney-/horseshoe-shaped and doughnut-shaped nuclei and abundant amphophilic cytoplasm. The nuclei in some of the other cells were often eccentrically located and appeared to be convoluted and even multilobulated. These large atypical cells displayed T-cell immunophenotype and were immunoreactive with CD30 antibody. The diagnosis was confirmed by a core-needle biopsy. This is the first case of primary hepatic ALCL reported in the English cytological literature.

publication date

  • August 2005



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1002/dc.20307

PubMed ID

  • 16007654

Additional Document Info

start page

  • 106

end page

  • 9


  • 33


  • 2