Contributions of the hippocampus and the striatum to simple association and frequency-based learning Academic Article uri icon


MeSH Major

  • Hippocampus
  • Learning
  • Neostriatum


  • Using fMRI and a learning paradigm, this study examined the independent contributions of the hippocampus and striatum to simple association and frequency-based learning. We scanned 10 right-handed young adult subjects using a spiral in/out sequence on a GE 3.0 T scanner during performance of the learning paradigm. The paradigm consisted of 2 cues that predicted each of 3 targets with varying probabilities. Simultaneously, we varied the frequency with which each target was presented throughout the task, independent of cue associations. Subjects had shorter response latencies to frequently occurring and highly associated target stimuli and longer response latencies to infrequent target stimuli, indicating learning. Imaging results showed increased caudate activity to infrequent relative to frequent targets and increased hippocampal activity to infrequent relative to frequent cue-target associations. This work provides evidence of different neural mechanisms underlying learning based on simple frequencies versus associations within a single paradigm.

publication date

  • August 15, 2005



  • Academic Article



  • eng

PubMed Central ID

  • PMC2517901

Digital Object Identifier (DOI)

  • 10.1016/j.neuroimage.2005.02.035

PubMed ID

  • 16061152

Additional Document Info

start page

  • 291

end page

  • 8


  • 27


  • 2