IDH1 mutations disrupt blood, brain, and barriers. Article uri icon

Overview

abstract

  • The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collagen and prolyl hydroxylases lead to altered microenvironment and defective angiogenesis.

publication date

  • September 11, 2012

Research

keywords

  • Brain
  • Hematopoietic Stem Cells
  • Hematopoietic System
  • Isocitrate Dehydrogenase
  • Mutation

Identity

Scopus Document Identifier

  • 84866038635

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2012.08.022

PubMed ID

  • 22975371

Additional Document Info

volume

  • 22

issue

  • 3