New polyether triterpenoids from Laurencia viridis and their biological evaluation. Academic Article uri icon

Overview

abstract

  • The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.

publication date

  • November 7, 2011

Research

keywords

  • Antineoplastic Agents
  • Laurencia
  • Neoplasms
  • Triterpenes

Identity

PubMed Central ID

  • PMC3229232

Scopus Document Identifier

  • 82655174093

Digital Object Identifier (DOI)

  • 10.3390/md9112220

PubMed ID

  • 22163183

Additional Document Info

volume

  • 9

issue

  • 11