Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle
Academic Article
Overview
MeSH Major
Antigens, Dermatophagoides
Bronchial Hyperreactivity
Muscle, Smooth
Trachea
abstract
These findings are the first to demonstrate that the dust mite allergen, Der p 1, can directly elicit changes in ASM responsiveness that are associated with activation of MAPK signaling, wherein proasthmatic effects induced by Der p 1 are attributed to activation of ERK1/2, whereas coactivation of p38 MAPK exerts a homeostatic action by negatively regulating ERK1/2 signaling.
