Proasthmatic effects and mechanisms of action of the dust mite allergen, Der p 1, in airway smooth muscle Academic Article uri icon

Overview

MeSH Major

  • Antigens, Dermatophagoides
  • Bronchial Hyperreactivity
  • Muscle, Smooth
  • Trachea

abstract

  • These findings are the first to demonstrate that the dust mite allergen, Der p 1, can directly elicit changes in ASM responsiveness that are associated with activation of MAPK signaling, wherein proasthmatic effects induced by Der p 1 are attributed to activation of ERK1/2, whereas coactivation of p38 MAPK exerts a homeostatic action by negatively regulating ERK1/2 signaling.

publication date

  • July 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jaci.2005.03.046

PubMed ID

  • 15990780

Additional Document Info

start page

  • 94

end page

  • 101

volume

  • 116

number

  • 1