p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow Academic Article uri icon


MeSH Major

  • Bone Marrow Cells
  • Cell Cycle Proteins
  • Neovascularization, Pathologic
  • Proteins
  • Tumor Suppressor Proteins


  • Neoangiogenesis involves both bone marrow-derived myelomonocytic and endothelial progenitor cells as well as endothelial cells coopted from surrounding vessels. Cytokines induce these cells to proliferate, migrate, and exit the cell cycle to establish the vasculature; however, which cell cycle regulators play a role in these processes is largely unknown. Here, we report that mice lacking the cell cycle inhibitors p130 and p27 show defects in tumor neoangiogenesis, both in xenografts and spontaneously arising tumors. This defect is associated with impaired mobilization of endothelial and myelomonocytic angiogenic progenitors from the bone marrow. This article documents the role of these molecules in angiogenesis and further suggests that cell expansion and mobilization from the bone marrow of angiogenic precursors are separable events.

publication date

  • May 10, 2005



  • Academic Article



  • eng

PubMed Central ID

  • PMC1088064

Digital Object Identifier (DOI)

  • 10.1073/pnas.0405823102

PubMed ID

  • 15867156

Additional Document Info

start page

  • 6890

end page

  • 5


  • 102


  • 19