Role of protein kinase C-δ (PKC-δ) in the generation of the effects of IFN-α in chronic myelogenous leukemia cells Academic Article uri icon

Overview

MeSH Major

  • Interferon-alpha
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Protein Kinase C

abstract

  • Taken altogether, our data demonstrate that PKC-delta plays a critical role in Type I IFN signaling in BCR-ABL expressing cells, acting as a serine kinase for Stat1, to regulate transcriptional activation of interferon-regulated genes and induction of antileukemic responses.

publication date

  • May 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.exphem.2005.01.014

PubMed ID

  • 15850832

Additional Document Info

start page

  • 550

end page

  • 7

volume

  • 33

number

  • 5