Invasive filamentous fungal infections in allogeneic hematopoietic stem cell transplant recipients after recovery from neutropenia: clinical, radiologic, and pathologic characteristics. Academic Article uri icon

Overview

MeSH

  • Antifungal Agents
  • Female
  • Graft vs Host Disease
  • Histocytochemistry
  • Humans
  • Male
  • Middle Aged
  • Muromonab-CD3
  • Neutropenia
  • Radiography
  • Retrospective Studies
  • Survival Analysis
  • Transplantation, Homologous

MeSH Major

  • Adrenal Cortex Hormones
  • Aspergillosis
  • Aspergillus
  • Stem Cell Transplantation

abstract

  • Invasive filamentous fungal infection (IFFI) is an important cause of mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. We reviewed 22 consecutive cases of IFFI in allogeneic HSCT recipients at Roswell Park Cancer Institute. IFFI was diagnosed after neutrophil recovery in 21 patients (95%). All had received corticosteroids within 1 month prior to IFFI diagnosis. Fourteen (64%) presented with dyspnea, and only 7 (32%) were febrile. Aspergillus species were isolated in 18 (82%) cases. Thirty day mortality after IFFI diagnosis was associated with a higher mean daily dose of corticosteroids (P=0.02) and receiving OKT3 (P=0.01) within 1 month prior to IFFI diagnosis and serum creatinine>2 mg/dl at the time of diagnosis (P=0.004). Histopathologic material from biopsy or autopsy was available in 15 patients (68%). In 8 (53%), the predominant lung histopathology was an acellular coagulative necrosis and hyphal angioinvasion was observed in some of these cases. These findings have generally been observed in neutropenic patients but not in non-neutropenic HSCT recipients. The predominance of coagulative necrosis in our series may reflect the high doses of corticosteroids used to treat graft-versus-host disease (GVHD), which may have disabled leukocyte trafficking and hyphal killing.

publication date

  • February 2005

has subject area

  • Adrenal Cortex Hormones
  • Antifungal Agents
  • Aspergillosis
  • Aspergillus
  • Female
  • Graft vs Host Disease
  • Histocytochemistry
  • Humans
  • Male
  • Middle Aged
  • Muromonab-CD3
  • Neutropenia
  • Radiography
  • Retrospective Studies
  • Stem Cell Transplantation
  • Survival Analysis
  • Transplantation, Homologous

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s11046-004-5495-0

PubMed ID

  • 15770441

Additional Document Info

start page

  • 181

end page

  • 188

volume

  • 159

number

  • 2