Regulatory T cell content in the bone marrow graft does not predict the occurrence of acute GVHD. Academic Article uri icon

Overview

abstract

  • The subpopulation of regulatory T cells (Treg) was shown to play a key role in alloreactive responses. In allogeneic hematopoietic stem cell transplantation, several groups tested whether Treg content in transplants correlates with graft-versus-host disease (GVHD) with controversial results. In a retrospective study of 49 consecutive HLA-matched sibling transplantations, we studied the relationship between Treg content in bone marrow transplants and acute GVHD (aGVHD) occurrence. We observed a large variability in Treg in bone marrow grafts. However, contrary to previous observations in peripheral blood stem cells transplantation, we report that the Treg content of allogeneic bone marrow transplantation did not predict the occurrence of aGVHD.

publication date

  • August 5, 2010

Research

keywords

  • Bone Marrow Cells
  • Bone Marrow Transplantation
  • Graft Survival
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • T-Lymphocytes, Regulatory

Identity

Scopus Document Identifier

  • 79251531634

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2010.07.024

PubMed ID

  • 20691799

Additional Document Info

volume

  • 17

issue

  • 2