D-4F induces heme oxygenase-1 and extracellular superoxide dismutase, decreases endothelial cell sloughing, and improves vascular reactivity in rat model of diabetes Academic Article uri icon

Overview

MeSH Major

  • Diabetes Mellitus, Experimental
  • Endothelial Cells
  • Heme Oxygenase-1
  • Peptides
  • Superoxide Dismutase

abstract

  • We conclude that an increase in circulating endothelial cell sloughing, superoxide anion, and vasoconstriction in diabetic rats can be prevented by administration of D-4F, which is associated with an increase in 2 antioxidant proteins, HO-1 and EC-SOD.

publication date

  • June 14, 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.104.517102

PubMed ID

  • 15939814

Additional Document Info

start page

  • 3126

end page

  • 34

volume

  • 111

number

  • 23