Gastric mucosa-associated lymphoid tissue lymphoma detected by clonotypic polymerase chain reaction despite continuous pathologic remission induced by involved-field radiotherapy Academic Article uri icon

Overview

MeSH Major

  • DNA, Neoplasm
  • Immunoglobulin Heavy Chains
  • Lymphoma, B-Cell, Marginal Zone
  • Polymerase Chain Reaction
  • Radiotherapy Dosage

abstract

  • Despite sustained biopsy-proven remissions for as long as 117 months after radiation, the vast majority of patients remain positive by clonotypic PCR. This suggests that the malignant clone is present but missing either an internal or external signal essential to the cancer phenotype. One possibility is that radiation eradicates the polyclonal H pylori-specific T cells eliminating critical local factors necessary for proliferation of the monoclonal B cells.

publication date

  • December 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2005.10.018

PubMed ID

  • 15923573

Additional Document Info

start page

  • 3768

end page

  • 72

volume

  • 23

number

  • 16