Clonal light chain restricted primary intrapulmonary nodular amyloidosis Academic Article uri icon


MeSH Major

  • Amyloidosis
  • Immunoglobulin Light Chains
  • Lung Diseases
  • Paraproteinemias


  • Primary intrapulmonary nodular amyloidosis is a rare form of immunoglobulin associated amyloidosis, also falling under the alternative appellation of amyloidoma. Although amyloidomas in other organ sites may be reflective of a localized or more generalized plasma cell dyscrasia, in the context of its presentation in the lung the presumptive basis has long been held to be one of chronic inflammation. We encountered 2 patients with nodular amyloidosis in whom the pathologic examination disclosed the basis to be one of a light chain restricted clonal lymphocytic plasma cell infiltrate, although without morphologic features of coexisting pulmonary lymphoma. These 2 patients serve to underscore the potential categorization of some cases of pulmonary nodular amyloidosis as a form of low grade B cell lymphoproliferative disease.

publication date

  • July 2005



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.athoracsur.2004.03.075

PubMed ID

  • 15975406

Additional Document Info

start page

  • 344

end page

  • 7


  • 80


  • 1