Necrotizing vasculopathy of the CNS: Case report Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Lymphoma
  • Pneumocystis Infections
  • Pneumonia, Pneumocystis
  • Vasculitis

abstract

  • A 62-year-old man with progressive cerebellar and brainstem dysfunction had gadolinium-enhancing lesions in basal ganglia and occipital lobe on MRI suggestive of primary CNS lymphoma (PCNSL). The patient, who had been treated with high-dose steroid hormones for several months, developed respiratory failure and expired before a histological diagnosis could be obtained. The postmortem examination showed Pneumocystis cariniiwas the cause of death. Pathology of the brain showed a necrotizing vasculopathy affecting the white matter of the cerebrum and cerebellum with involvement of the basal ganglia and the periventricular gray matter. Other organs such as liver, lung, and kidneys were spared. Necrotizing vasculopathy is a novel entity that should be considered in the differential diagnosis of PCNSL.

publication date

  • April 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s11060-004-2063-x

PubMed ID

  • 15926001

Additional Document Info

start page

  • 191

end page

  • 3

volume

  • 72

number

  • 2