Botox and Collagen for Glabellar Furrows: Advantages of Combination Therapy Academic Article Article uri icon


MeSH Major

  • Retina
  • Retinal Diseases
  • Vitreous Body


  • Plastic surgeons frequently administer botulinum toxin A (Botox) or collagen as monotherapy to treat glabellar furrows. This study evaluates the possible advantages of combination therapy. Sixty-five patients with moderate to severe glabellar rhytids were prospectively randomized to receive standard injections of Botox, Zyderm II collagen, or a combination. Improvement in rhytids was assessed over 3 months using patient satisfaction scores and an independent physician evaluation. Baseline wrinkle severity was similar in all 3 groups. By 1 month posttreatment, the combination arm showed significantly greater improvement in furrows (79% compared with only 56% and 50% in the Botox and Zyderm arms, respectively; P < 0.05). At 3 months postinjection, the dual-therapy arm maintained better improvement (57% versus 33% and 27% in the monotherapy arms; P < 0.05). Patient satisfaction further highlighted the superiority of the combination approach. By simultaneously addressing the static and dynamic aspects of glabellar furrows, dual therapy provides optimal treatment of this problem.

publication date

  • May 2004



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1097/

PubMed ID

  • 15096921

Additional Document Info

start page

  • 442

end page

  • 7; discussion 447


  • 52


  • 5