Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Neoplasm
  • Antigens, Neoplasm
  • Melanoma

abstract

  • We studied how frequently patients with malignant melanoma have specific antibody to cell surface antigens of cultured autologous melanoma cells as demonstrated by mixed hemadsorption assays. Of 35 patients studied over periods ranging from 1 to 36 months with Stage II, III, and IV disease, two showed consistent and high titered reactivity against autologous melanoma cells, two showed less consistent and intermediate reactivity, seven showed sporatic, low titered reactivity, and the remainder were consistently negative. A detailed analysis was carried out with the sera of one patient with sufficiently high titer against autologous melanoma cells. By direct tests and by absorption analysis with a variety of melanoma and nonmelanoma cell lines which included autologous fibroblasts, the antigen could not be demonstrated on any cell type other than the autologous melanoma.

publication date

  • December 1976

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC431008

PubMed ID

  • 1067619

Additional Document Info

start page

  • 3278

end page

  • 82

volume

  • 73

number

  • 9