Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer Academic Article uri icon


MeSH Major

  • Adenocarcinoma
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms
  • Mutation
  • Protein-Tyrosine Kinases
  • Receptor, Epidermal Growth Factor


  • We evaluated somatic genetic alterations in the kinase domain of the EGFR gene in the tumors of 219 non-small cell lung cancer patients of primarily Caucasian and African American origins. We identified 26 patients (12%) whose tumors had a mutation in the EGFR gene, and 11 (5%) patients carried novel genomic variations consistent with germ-line polymorphisms. All but one mutation were identified in Caucasian patients affected with adenocarcinoma. EGFR mutations were more frequent in women and in nonsmokers, but a significant portion of the affected patients were men (12 of 26) and current or past smokers accounted for half of the patients affected (13 of 26). Screening subjects with EGFR mutations may identify patients whose tumors could respond to targeted therapy using tyrosine kinase inhibitors.

publication date

  • March 15, 2005



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-04-1853

PubMed ID

  • 15788655

Additional Document Info

start page

  • 2106

end page

  • 10


  • 11


  • 6