Gene expression profiling in chronic inflammatory demyelinating polyneuropathy Academic Article uri icon

Overview

MeSH Major

  • Demyelinating Diseases
  • Gene Expression Profiling
  • Polyneuropathies

abstract

  • Gene expression in archived frozen sural nerve biopsies of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) was compared to that in vasculitic nerve biopsies (VAS) and to normal nerve (NN) by DNA microarray technology. Hierarchical clustering analysis demonstrated distinct gene expression patterns distinguishing these disease groups. Of particular interest were: (1) Tachykinin precursor 1, which may be involved in pain mediation; (2) Stearoyl-CoA-desaturase, which may be a marker for remyelination and (3) the Allograft Inflammatory Factor 1 (AIF-1), a modulator of immune response during macrophage activation. Differential gene expression may help distinguish between CIDP, VAS and NN in sural nerve biopsies and identify genes that may be involved in disease pathogenesis.

publication date

  • February 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jneuroim.2004.10.021

PubMed ID

  • 15652421

Additional Document Info

start page

  • 203

end page

  • 14

volume

  • 159

number

  • 1-2