Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Non-Small-Cell Lung
  • Gene Expression Regulation, Neoplastic
  • Immunohistochemistry
  • Lung Neoplasms
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53

abstract

  • Some cumulative abnormalities in the Rb and p53 pathways (e.g., cyclin D1 overexpression and p53 mutations) significantly cooperate to predict a poor prognosis; however, the complexity of the cell cycle protein interaction in any given tumor warrants caution in interpreting survival results when specific protein abnormalities are taken in isolation.

publication date

  • January 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 15671551

Additional Document Info

start page

  • 232

end page

  • 41

volume

  • 11

number

  • 1