Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. Academic Article uri icon

Overview

abstract

  • We report here that nitazoxanide (NTZ) and its active metabolite kill replicating and nonreplicating M. tuberculosis at low microg/mL levels. NTZ appears to evade resistance, as we were unable to recover resistant colonies, using up to 10(12) colony forming units. Therefore, NTZ is a novel lead compound that kills replicating and nonreplicating M. tuberculosis by a novel mechanism of action, which appears to bypass the development of resistance.

publication date

  • October 8, 2009

Research

keywords

  • Mycobacterium tuberculosis
  • Thiazoles

Identity

Scopus Document Identifier

  • 70349647606

Digital Object Identifier (DOI)

  • 10.1021/jm9010719

PubMed ID

  • 19736929

Additional Document Info

volume

  • 52

issue

  • 19