The impairment of preconditioning-mediated cardioprotection in pathological conditions. Review uri icon

Overview

abstract

  • Myocardial ischemia is a condition in which the blood flow to the heart is diminished and thus the supply of oxygen and nutrients to the heart is reduced. The reperfusion to an ischemic myocardium often results in induction of infarction and cardiac dysfunction. The brief episodes of ischemia and reperfusion given before prolonged ischemia and reperfusion denotes ischemic preconditioning, which protects the heart from lethal ischemia-reperfusion injury. However, it is intriguing to note that the cardioprotective effect of preconditioning is suppressed in some pathological conditions such as hypercholesterolemia, hyperglycemia, hypertension, cardiac hypertrophy, aging, obesity and hyperhomocysteinemia. In this review, we have critically discussed the possible mechanisms involved in the modulation of cardioprotective potential of ischemic preconditioning in various pathological conditions.

publication date

  • March 13, 2009

Research

keywords

  • Ischemic Preconditioning, Myocardial
  • Myocardial Ischemia

Identity

Scopus Document Identifier

  • 67349134832

Digital Object Identifier (DOI)

  • 10.1016/j.phrs.2009.03.002

PubMed ID

  • 19427581

Additional Document Info

volume

  • 60

issue

  • 1