Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice Academic Article uri icon

Overview

MeSH Major

  • DNA-Binding Proteins
  • Disease Models, Animal
  • Gene Expression
  • Lymphoma, B-Cell
  • Lymphoma, Large B-Cell, Diffuse

abstract

  • Diffuse large B cell lymphomas (DLBCL) derive from germinal center (GC) B cells and display chromosomal alterations deregulating the expression of BCL6, a transcriptional repressor required for GC formation. To investigate the role of BCL6 in DLBCL pathogenesis, we have engineered mice that express BCL6 constitutively in B cells by mimicking a chromosomal translocation found in human DLBCL. These mice display increased GC formation and perturbed post-GC differentiation characterized by a decreased number of post-isotype switch plasma cells. Subsequently, these mice develop a lymphoproliferative syndrome that culminates with the development of lymphomas displaying features typical of human DLBCL. These results define the oncogenic role of BCL6 in the pathogenesis of DLBCL and provide a faithful mouse model of this common disease.

publication date

  • May 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2005.03.037

PubMed ID

  • 15894265

Additional Document Info

start page

  • 445

end page

  • 55

volume

  • 7

number

  • 5