Roles of semaphorins in the immune and hematopoietic system. Review uri icon

Overview

abstract

  • Semaphorins were originally discovered in the nervous system, and have been implicated in repulsive axon guidance during the development of nervous system. Semaphorins are also implicated in tumor progression, by affecting adhesion, migration of malignant cells and angiogenesis, and are involved in normal cardiovascular development. Recently, several semaphorins and their receptors are expressed in a variety of lymphoid and myeloid cells, and affect immune cell functions, including cell proliferation, differentiation, chemotaxis, and cytokine production. This review focuses on recent work on the functions of semaphorins in the immune system and autoimmune diseases.

publication date

  • January 13, 2009

Research

keywords

  • Hematopoietic System
  • Immune System
  • Semaphorins

Identity

Scopus Document Identifier

  • 67349134964

Digital Object Identifier (DOI)

  • 10.1007/s00296-009-0852-4

PubMed ID

  • 19139899

Additional Document Info

volume

  • 29

issue

  • 7