Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries Academic Article uri icon

Overview

MeSH Major

  • Coronary Artery Disease
  • Coronary Vessels
  • Endothelium, Vascular
  • Ginsenosides
  • Homocysteine

abstract

  • Homocysteine (Hcy) is an independent risk factor for atherosclerosis and other vascular lesions. It causes endothelial dysfunction and oxidative stress. Ginseng compounds have effects of vasorelaxation and antioxidation. The purpose of this study was to determine the effect of ginsenoside Rb1, a major constituent of ginseng, on Hcy-induced endothelial dysfunction and molecular changes in porcine coronary arteries. Our results showed that ginsenoside Rb1 can effectively block Hcy-induced dysfunction of endothelium-dependent vasorelaxation as well as superoxide anion production and eNOS downregulation. This study suggests that ginseng compounds may have potential clinical applications in controlling Hcy-associated vascular diseases and other vascular lesions.

publication date

  • May 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jvs.2005.01.054

PubMed ID

  • 15886672

Additional Document Info

start page

  • 861

end page

  • 8

volume

  • 41

number

  • 5