Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3 β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter
The radiosynthesis of a novel tropane derivative [123I]KUC-25019, [[123I] N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3β (3′,4′-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the 123I-labeling synthesis. The no-carrier-added 123I-labeling has about 20% yield, the specific activity of [123I]KUC-25019 is > 107 GBq/μmol and the radiochemical purity of [123I] KUC-25019 is >95%. Copyright © 2002 John Wiley & Sons, Ltd.
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