Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3 β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter Academic Article uri icon

Overview

MeSH Major

  • Amyloid beta-Peptides
  • Blood Pressure
  • Brain
  • Brain Mapping

abstract

  • The radiosynthesis of a novel tropane derivative [123I]KUC-25019, [[123I] N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3β (3′,4′-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the 123I-labeling synthesis. The no-carrier-added 123I-labeling has about 20% yield, the specific activity of [123I]KUC-25019 is > 107 GBq/μmol and the radiochemical purity of [123I] KUC-25019 is >95%. Copyright © 2002 John Wiley & Sons, Ltd.

publication date

  • October 30, 2002

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/jlcr.619

Additional Document Info

start page

  • 1011

end page

  • 1017

volume

  • 45

number

  • 12