Docetaxel (Taxotere) Induced Subacute Cutaneous Lupus Erythematosus: Report of 4 Cases Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents, Phytogenic
  • Lupus Erythematosus, Cutaneous
  • Taxoids

abstract

  • Pathogenetically, docetaxel may evoke a lupus-like eruption through its proapoptotic effects on replicating cells, which could in turn provoke the release of nucleosomes postulated to be target antigens in LE. It seems reasonable to postulate that the rapidly replicating keratinocyte, when subjected to the cytotoxic effects of docetaxel, would also manifest nucleosome release followed by a local autoimmune reaction in a genetically predisposed host.

publication date

  • April 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 15088316

Additional Document Info

start page

  • 818

end page

  • 20

volume

  • 31

number

  • 4