p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Carcinoma, Transitional Cell
  • Cyclin-Dependent Kinase Inhibitor p16
  • Cyclins
  • Cystectomy
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53
  • Urinary Bladder Neoplasms

abstract

  • Although altered expression of each of the four cell cycle regulators is associated with bladder cancer outcome in patients undergoing radical cystectomy, p53 is the strongest predictor, followed by p21, suggesting a more pivotal role of the p53/p21 pathway in bladder cancer progression.

publication date

  • December 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2004.03.118

PubMed ID

  • 14981102

Additional Document Info

start page

  • 1014

end page

  • 24

volume

  • 22

number

  • 6