p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer
Carcinoma, Transitional Cell
Cyclin-Dependent Kinase Inhibitor p16
Tumor Suppressor Protein p53
Urinary Bladder Neoplasms
Although altered expression of each of the four cell cycle regulators is associated with bladder cancer outcome in patients undergoing radical cystectomy, p53 is the strongest predictor, followed by p21, suggesting a more pivotal role of the p53/p21 pathway in bladder cancer progression.