Clonal genetic alterations in the lungs of current and former smokers Academic Article uri icon

Overview

MeSH Major

  • Chromosome Deletion
  • Chromosomes, Human, Pair 17
  • Chromosomes, Human, Pair 3
  • Chromosomes, Human, Pair 9
  • DNA Damage
  • Lung Neoplasms
  • Smoking

abstract

  • Genetic alterations at chromosomal sites containing putative tumor-suppressor genes (i.e., 3p14 and the FHIT gene, 9p21 and the p16 gene [also known as CDKN2], and 17p13 and the p53 gene [also known as TP53]) occur frequently in the histologically normal or minimally altered bronchial epithelium of chronic smokers.

publication date

  • June 18, 1997

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 9196251

Additional Document Info

start page

  • 857

end page

  • 62

volume

  • 89

number

  • 12