Therapeutic cloning in individual parkinsonian mice. Academic Article uri icon

Overview

abstract

  • Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.

authors

  • Tabar, Viviane S.
  • Tomishima, Mark
  • Panagiotakos, Georgia
  • Wakayama, Sayaka
  • Menon, Jayanthi
  • Chan, Bill
  • Mizutani, Eiji
  • Al-Shamy, George
  • Ohta, Hiroshi
  • Wakayama, Teruhiko
  • Studer, Lorenz

publication date

  • March 23, 2008

Research

keywords

  • Embryonic Stem Cells
  • Parkinsonian Disorders

Identity

PubMed Central ID

  • PMC2786166

Scopus Document Identifier

  • 41849093685

Digital Object Identifier (DOI)

  • 10.1038/nm1732

PubMed ID

  • 18376409

Additional Document Info

volume

  • 14

issue

  • 4