Adipocyte-derived cytokine resistin causes endothelial dysfunction of porcine coronary arteries Academic Article uri icon

Overview

MeSH Major

  • Coronary Vessels
  • Endothelial Cells
  • Hormones, Ectopic
  • Vasodilation

abstract

  • Obesity has been considered to be an independent risk factor for coronary artery disease and other vascular lesions. Resistin is a newly discovered adipocyte-derived cytokine, and its plasma levels are increased in obese individuals. However, it is not clear whether resistin could directly contribute to vascular disease formation. This study showed that resistin can cause endothelial dysfunction in porcine coronary arteries through oxidative stress and down-regulation of eNOS. Thus, this study may suggest a new mechanism of obesity-associated vascular disease and that antioxidants may effectively prevent vascular disease in obese individuals.

publication date

  • April 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jvs.2004.12.046

PubMed ID

  • 15874935

Additional Document Info

start page

  • 691

end page

  • 8

volume

  • 41

number

  • 4