All-trans retinoic acid and interferon-α-2a in patients with metastatic or recurrent carcinoma of the uterine cervix: Clinical and pharmacokinetic studies Academic Article Article uri icon

Overview

MeSH Major

  • Carcinoma
  • Lung
  • Lung Neoplasms
  • Tomography, X-Ray Computed

abstract

  • The combination of tRA + IFN alpha was inactive in patients with advanced carcinoma of the cervix when employed at these doses on either the daily or intermittent schedule. The failure of activity of this regimen did not result from induction of metabolism of tRA, suggesting that intrinsic mechanisms of resistance to tRA at the cellular level may be of greater importance.

publication date

  • April 15, 1997

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/(SICI)1097-0142(19970415)79:8<1574::AID-CNCR20>3.0.CO;2-U

PubMed ID

  • 9118041

Additional Document Info

start page

  • 1574

end page

  • 80

volume

  • 79

number

  • 8