Prognostic impact of trisomies of chromosomes and 5 among children with acute lymphoblastic leukemia and high hyperdiploidy (> 50 chromosomes)
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 5
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Trisomy of chromosomes 10 and 17 as well as modal chromosome number 54 to 58 identify subgroups of patients with high-hyperdiploid ALL who have a better outcome than high-hyperdiploid patients who lack these cytogenetic features. Trisomy of chromosome 5 confers poorer outcome among high-hyperdiploid patients.