Modulation of matrix metalloproteinase activity in human saphenous vein grafts using adenovirus-mediated gene transfer Academic Article Article uri icon

Overview

MeSH Major

  • Foot
  • Free Tissue Flaps
  • Hand
  • Reconstructive Surgical Procedures
  • Sarcoma

abstract

  • MMP-3 and TIMP activity can be regulated in hSVGs by replication-deficient recombinant adenoviruses. We have previously demonstrated that MMP-3 or TIMP-1 transduction, or both, inhibit SMC migration in an in vitro reconstituted vessel wall. Modulation of MMP activity may thus afford high patency rates in genetically engineered hSVGs. However, adenovirus-mediated gene delivery is limited to the vessel's intima; strategies to infect medial smooth muscle cells need to be developed.

publication date

  • August 24, 1998

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0039-6060(98)70112-6

PubMed ID

  • 9706130

Additional Document Info

start page

  • 129

end page

  • 36

volume

  • 124

number

  • 2