Malaria virulence genes controlling expression through chromatin modification. Academic Article Comment uri icon

Overview

MeSH

  • Animals
  • Cell Nucleus
  • Chromatin Assembly and Disassembly
  • Gene Expression Regulation
  • Genes, Protozoan
  • Plasmids
  • Telomere
  • Virulence

MeSH Major

  • Antigenic Variation
  • Cell Compartmentation
  • Gene Silencing
  • Heterochromatin
  • Malaria, Falciparum
  • Plasmodium falciparum

abstract

  • Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh et al., 2005; Freitas-Junior et al., 2005).

publication date

  • April 8, 2005

has subject area

  • Animals
  • Antigenic Variation
  • Cell Compartmentation
  • Cell Nucleus
  • Chromatin Assembly and Disassembly
  • Gene Expression Regulation
  • Gene Silencing
  • Genes, Protozoan
  • Heterochromatin
  • Malaria, Falciparum
  • Plasmids
  • Plasmodium falciparum
  • Telomere
  • Virulence

Research

keywords

  • Comment
  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2005.03.019

PubMed ID

  • 15820670

Additional Document Info

start page

  • 1

end page

  • 2

volume

  • 121

number

  • 1