Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Academic Article uri icon

Overview

MeSH

  • Administration, Oral
  • Adolescent
  • Adult
  • Colonic Neoplasms
  • Cytosine Deaminase
  • Escherichia coli
  • Female
  • Humans
  • Male
  • Nucleoside Deaminases
  • Virus Replication

MeSH Major

  • Adenoviridae
  • Antimetabolites
  • Flucytosine
  • Genetic Therapy
  • Genetic Vectors
  • Liver Neoplasms
  • Prodrugs

publication date

  • May 20, 1997

has subject area

  • Adenoviridae
  • Administration, Oral
  • Adolescent
  • Adult
  • Antimetabolites
  • Colonic Neoplasms
  • Cytosine Deaminase
  • Escherichia coli
  • Female
  • Flucytosine
  • Genetic Therapy
  • Genetic Vectors
  • Humans
  • Liver Neoplasms
  • Male
  • Nucleoside Deaminases
  • Prodrugs
  • Virus Replication

Research

keywords

  • Clinical Trial
  • Clinical Trial, Phase I
  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1089/hum.1997.8.8-985

PubMed ID

  • 9195221

Additional Document Info

start page

  • 985

end page

  • 1001

volume

  • 8

number

  • 8