Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome
Antineoplastic Combined Chemotherapy Protocols
Cell Cycle Proteins
Tumor Suppressor Proteins
Our results indicate that positive p27 expression in rectal cancer after preoperative chemoradiation is an independent negative predictor of RFS. Expression of p27 in the residual rectal cancer may therefore identify patients with disease likely to be refractory to standard therapy and for whom investigational approaches should be strongly considered.