Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome Academic Article uri icon

Overview

MeSH Major

  • Antimetabolites, Antineoplastic
  • Antineoplastic Combined Chemotherapy Protocols
  • Biomarkers, Tumor
  • Cell Cycle Proteins
  • Enzyme Inhibitors
  • Fluorouracil
  • Rectal Neoplasms
  • Tumor Suppressor Proteins

abstract

  • Our results indicate that positive p27 expression in rectal cancer after preoperative chemoradiation is an independent negative predictor of RFS. Expression of p27 in the residual rectal cancer may therefore identify patients with disease likely to be refractory to standard therapy and for whom investigational approaches should be strongly considered.

publication date

  • December 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1245/ASO.2004.03.095

PubMed ID

  • 15525823

Additional Document Info

start page

  • 955

end page

  • 61

volume

  • 11

number

  • 11