Pulsatile administration of the epidermal growth factor receptor inhibitor gefitinib is significantly more effective than continuous dosing for sensitizing tumors to paclitaxel Academic Article uri icon


MeSH Major

  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Antineoplastic Combined Chemotherapy Protocols
  • Paclitaxel
  • Quinazolines


  • The results suggest that the dose and schedule of an EGFR inhibitor required to effectively inhibit proliferation may differ from that required to stimulate apoptosis or to induce other effects. The former may require continuous EGFR inhibition to maintain cell cycle arrest, whereas sensitization to apoptosis may be optimally induced by profound but temporary inhibition of survival pathways. Our data suggest that the effects of receptor inhibition vary as a function of dose and schedule and that continuous administration of tyrosine kinase inhibitors may not be the best schedule with which to combine such agents with taxanes.

publication date

  • March 2005



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-04-1347

PubMed ID

  • 15756024

Additional Document Info

start page

  • 1983

end page

  • 9


  • 11


  • 5