Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses Academic Article uri icon

Overview

MeSH Major

  • Dendritic Cells
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • Receptors, Cell Surface
  • Transfection

abstract

  • caTLR4 increases the CTL-inducing capacity of DC generating a lytic response specific for the accompanying antigen. These results demonstrate the possibility of enhancing the immunogenicity of the native MART-1 and other RNA derived from weakly immunogenic tumors in DC-based immunotherapy.

publication date

  • April 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jss.2004.10.002

PubMed ID

  • 15820257

Additional Document Info

start page

  • 264

end page

  • 73

volume

  • 124

number

  • 2