Panel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations. Academic Article uri icon

Overview

abstract

  • We have created a panel of recombinant HIV-1 infectious clones containing common patterns of reverse transcriptase (RT) mutations responsible for resistance to each of the currently available nucleoside reverse transcriptase inhibitors (NRTI), and we have submitted the panel to the National Institutes of Health AIDS Research and Reference Reagent Programme. Testing the activity of new antiretroviral compounds against this panel of drug-resistant clones will determine their relative activity against many clinically relevant NRTI-resistant viruses.

publication date

  • April 29, 2005

Research

keywords

  • HIV Infections
  • HIV Reverse Transcriptase
  • HIV-1
  • Mutation

Identity

PubMed Central ID

  • PMC2573397

Scopus Document Identifier

  • 17844409371

PubMed ID

  • 15821401

Additional Document Info

volume

  • 19

issue

  • 7