Revised Recommendations of the International Working Group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia Review uri icon


MeSH Major

  • Clinical Trials as Topic
  • Leukemia, Myeloid, Acute


  • An International Working Group met to revise the diagnostic and response criteria for acute myelogenous leukemia originally published in 1990, as well as to provide definitions of outcomes and reporting standards to improve interpretability of data and comparisons among trials. Since the original publication, there have been major advances in our understanding of the biology and molecular genetics of acute leukemia that are clinically relevant and warrant incorporation into response definitions. Differences from the 1990 recommendations included a category of leukemia-free state, new criteria for complete remission, including cytogenetic and molecular remissions and remission duration. Storage of viable blasts for correlative studies is important for future progress in the therapy of these disorders.

publication date

  • December 15, 2003



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2003.04.036

PubMed ID

  • 14673054

Additional Document Info

start page

  • 4642

end page

  • 9


  • 21


  • 24