A Toll-like Receptor That Prevent Infection by Uropathogenic Bacteria Academic Article uri icon

Overview

MeSH Major

  • Escherichia coli
  • Escherichia coli Infections
  • Kidney
  • Receptors, Cell Surface
  • Urinary Bladder
  • Urinary Tract Infections

abstract

  • Toll-like receptors (TLRs) recognize molecular patterns displayed by microorganisms, and their subsequent activation leads to the transcription of appropriate host-defense genes. Here we report the cloning and characterization of a member of the mammalian TLR family, TLR11, that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. Cells expressing TLR11 fail to respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. Mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating a potentially important role for TLR11 in preventing infection of internal organs of the urogenital system.

publication date

  • March 5, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1094351

PubMed ID

  • 15001781

Additional Document Info

start page

  • 1522

end page

  • 6

volume

  • 303

number

  • 5663