Intravenous antidepressants: A review Review uri icon

Overview

MeSH Major

  • Antidepressive Agents
  • Depressive Disorder, Major

abstract

  • Antidepressant medications have an onset of action of several weeks and have moderate efficacy. Their mode of administration is oral (p.o.). Some clinicians wondered whether intravenous (i.v.) administration would speed onset of action and increase efficacy. In this article we review controlled studies on i.v. administration of antidepressants. These include clomipramine, citalopram, and other antidepressants. Overall these studies do not support increased efficacy of i.v. over p.o.administration but there are suggestions of a faster onset of action. In one study i.v. citalopram showed superior response rates over p.o. citalopram (79% vs. 63%) in severely depressed patients at 8 weeks.

publication date

  • March 16, 2004

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/da.10135

PubMed ID

  • 14978779

Additional Document Info

start page

  • 1

end page

  • 9

volume

  • 19

number

  • 1