Genomic approaches in the management and treatment of breast cancer Review uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Breast Neoplasms
  • Genetic Markers
  • Oligonucleotide Array Sequence Analysis

abstract

  • Breast cancer is the most common malignancy afflicting women from Western cultures. It has been estimated that approximately 211 000 women will be diagnosed with breast cancer in 2003 in the United States alone, and each year over 40 000 women will die of this disease. Developments in breast cancer molecular and cellular biology research have brought us closer to understanding the genetic basis of this disease. Unfortunately, this information has not yet been incorporated into the routine diagnosis and treatment of breast cancer in the clinic. Recent advancements in microarray technology hold the promise of further increasing our understanding of the complexity and heterogeneity of this disease, and providing new avenues for the prognostication and prediction of breast cancer outcomes. The most recent application of microarray genomic technologies to studying breast cancer will be the focus of this review.

publication date

  • February 28, 2005

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC2361866

Digital Object Identifier (DOI)

  • 10.1038/sj.bjc.6602410

PubMed ID

  • 15714204

Additional Document Info

start page

  • 618

end page

  • 24

volume

  • 92

number

  • 4