Adenovirus-based genetic vaccines for biodefense. Review uri icon

Overview

MeSH

  • Genetic Vectors
  • HIV-1
  • Humans
  • Viral Proteins

MeSH Major

  • AIDS Vaccines
  • Adenoviridae
  • Bioterrorism
  • Communicable Disease Control
  • Genetic Therapy
  • HIV Infections

abstract

  • The robust host responses elicited against transgenes encoded by (E1-)(E3-) adenovirus (Ad) gene transfer vectors can be used to develop Ad-based vectors as platform technologies for vaccines against potential bioterror pathogens. This review focuses on pathogens of major concern as bioterror agents and why Ad vectors are ideal as anti-bioterror vaccine platforms, providing examples from our laboratories of using Ad vectors as vaccines against potential bioterror pathogens and how Ad vectors can be developed to enhance vaccine efficacy in the bioterror war.

publication date

  • February 2005

has subject area

  • AIDS Vaccines
  • Adenoviridae
  • Bioterrorism
  • Communicable Disease Control
  • Genetic Therapy
  • Genetic Vectors
  • HIV Infections
  • HIV-1
  • Humans
  • Viral Proteins

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1089/hum.2005.16.157

PubMed ID

  • 15761256

Additional Document Info

start page

  • 157

end page

  • 168

volume

  • 16

number

  • 2