Evolutionary genomics: codon bias and selection on single genomes. Academic Article Comment uri icon

Overview

MeSH

  • Bias (Epidemiology)
  • Models, Genetic
  • Mutation, Missense
  • Mycobacterium tuberculosis
  • Reproducibility of Results

MeSH Major

  • Biological Evolution
  • Codon
  • Genome, Bacterial
  • Genomics
  • Selection, Genetic

abstract

  • The idea that natural selection on genes might be detected using only a single genome has been put forward by Plotkin and colleagues, who present a method that they claim can detect selection without the need for comparative data and which, if correct, would confer greater power of analysis with less information. Here we argue that their method depends on assumptions that confound their conclusions and that, even if these assumptions were valid, the authors' inferences about adaptive natural selection are unjustified.

publication date

  • January 20, 2005

has subject area

  • Bias (Epidemiology)
  • Biological Evolution
  • Codon
  • Genome, Bacterial
  • Genomics
  • Models, Genetic
  • Mutation, Missense
  • Mycobacterium tuberculosis
  • Reproducibility of Results
  • Selection, Genetic

Research

keywords

  • Comment
  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nature03221

PubMed ID

  • 15662370

Additional Document Info

start page

  • E5

end page

  • 6; discussion E7-8

volume

  • 433

number

  • 7023