A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron. Academic Article uri icon

Overview

MeSH

  • Animals
  • Gene Expression Regulation
  • Genes, Reporter
  • Plasmids

MeSH Major

  • Gene Deletion
  • Gene Silencing
  • Introns
  • Plasmodium falciparum
  • Promoter Regions, Genetic

abstract

  • Introns of Plasmodium falciparum var genes act as transcriptional silencing elements that help control antigenic variations. In transfected episomes, intron silencing of a drug-selectable marker under var promoter control is reversed by the spontaneous deletion of key intron regions. The resulting promoter activation does not affect the transcription of chromosomal var genes.

publication date

  • February 2005

has subject area

  • Animals
  • Gene Deletion
  • Gene Expression Regulation
  • Gene Silencing
  • Genes, Reporter
  • Introns
  • Plasmids
  • Plasmodium falciparum
  • Promoter Regions, Genetic

Research

keywords

  • Journal Article

Identity

Language

  • eng

PubMed Central ID

  • PMC549332

Digital Object Identifier (DOI)

  • 10.1128/EC.4.2.490-492.2005

PubMed ID

  • 15701812

Additional Document Info

start page

  • 490

end page

  • 492

volume

  • 4

number

  • 2