Herpesvirus 8 inclusions in primary effusion lymphoma: Report of a unique case with T-cell phenotype Academic Article uri icon

Overview

MeSH Major

  • Herpesviridae Infections
  • Herpesvirus 8, Human
  • Lymphoma
  • Pleural Effusion, Malignant
  • T-Lymphocytes

abstract

  • We describe a case of primary effusion lymphoma with T-cell phenotype, mixed genotype, and intranuclear herpesvirus inclusions visible with the light microscope. Cells were studied by immunohistochemical analysis, in situ hybridization, immunoglobulin and T-cell receptor gene rearrangement, and polymerase chain reaction. Primary effusion lymphoma cells with T-cell phenotype revealed herpesvirus 8 inclusions predominantly seen in apoptotic cells, suggesting that productive viral infection is associated with cell death. Clinical features were typical of primary effusion lymphoma. Cytologic, molecular genetic, and phenotypic features demonstrated a unique variant of primary effusion lymphoma.

publication date

  • March 22, 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10086517

Additional Document Info

start page

  • 257

end page

  • 60

volume

  • 123

number

  • 3