Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy Academic Article uri icon

Overview

MeSH Major

  • Adenoviridae
  • Carcinoma, Non-Small-Cell Lung
  • Genes, p53
  • Lung Neoplasms
  • Tumor Suppressor Protein p53

abstract

  • Intratumoral injection of Ad-p53 (INGN 201) in combination with radiation therapy is well tolerated and demonstrates evidence of tumor regression at the primary injected tumor. Serial biopsies of the tumor suggest that BAK gene expression is most closely related to Ad-p53 (INGN 201) gene transfer.

authors

publication date

  • January 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12538456

Additional Document Info

start page

  • 93

end page

  • 101

volume

  • 9

number

  • 1 I