In vivo multiple-mouse imaging at 1.5 T. Academic Article uri icon

Overview

MeSH

  • Animals
  • Carcinoma, Lewis Lung
  • Equipment Design
  • Feasibility Studies
  • Glioma
  • Mice
  • Mice, Knockout
  • Mice, Transgenic

MeSH Major

  • Brain Neoplasms
  • Lung Neoplasms
  • Magnetic Resonance Imaging
  • Models, Animal

abstract

  • A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously to screen for tumors on a 1.5 T clinical scanner. For the coil to be effective as a screening tool, it should permit acquisition of MRIs in which orthotopic tumors with diameters >2 mm are detectable in a reasonable period of time (<1 hr magnet time) and their sizes accurately measured. Using a spin echo sequence, we demonstrated that this coil provides sufficient sensitivity for moderately high resolution images (156-176 microm in plane-resolution, 1.5 mm slice thickness). This spatial resolution permitted detection of primary brain tumors in transgenic/knockout mice and orthotopic xenografts. Brain tumor size as measured by MRI was correlated with size measured by histopathology (P < 0.001). Metastatic tumors in the mouse lung were also successfully imaged in a screening setting. The multiple mouse coil is simple in construction and may be implemented without any significant modification to the hardware or software on a clinical scanner. Copyright 2003 Wiley-Liss, Inc.

publication date

  • March 2003

has subject area

  • Animals
  • Brain Neoplasms
  • Carcinoma, Lewis Lung
  • Equipment Design
  • Feasibility Studies
  • Glioma
  • Lung Neoplasms
  • Magnetic Resonance Imaging
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Animal

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/mrm.10397

PubMed ID

  • 12594759

Additional Document Info

start page

  • 551

end page

  • 557

volume

  • 49

number

  • 3