Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Apoptosis
  • Cerebellum
  • Hippocampus
  • Neurons
  • PrPC Proteins

abstract

  • Neuronal death is a prominent, but poorly understood, pathological hallmark of prion disease. Notably, in the absence of the cellular prion protein (PrPC), the disease-associated isoform, PrPSc, appears not to be intrinsically neurotoxic, suggesting that PrPC itself may participate directly in the prion neurodegenerative cascade. Here, cross-linking PrPC in vivo with specific monoclonal antibodies was found to trigger rapid and extensive apoptosis in hippocampal and cerebellar neurons. These findings suggest that PrPC functions in the control of neuronal survival and provides a model to explore whether cross-linking of PrPC by oligomeric PrPSc can promote neuronal loss during prion infection.

publication date

  • March 5, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1094273

PubMed ID

  • 14752167

Additional Document Info

start page

  • 1514

end page

  • 6

volume

  • 303

number

  • 5663