Developmental Endothelial Locus-1 (Del-1), a Novel Angiogenic Protein: Its Role in Ischemia Academic Article uri icon

Overview

MeSH Major

  • Angiogenic Proteins
  • Carrier Proteins
  • Collateral Circulation
  • Hindlimb
  • Ischemia

abstract

  • Del-1 is expressed in ischemic tissue. Del-1 stimulates angiogenesis, an effect that is dependent on the RGD motif and a second signaling sequence in the discoidin-I-like domain. Exogenous intramuscular administration of Del-1 significantly enhances angiogenesis in the murine ischemic hindlimb. Del-1 may prove to be a novel therapeutic agent for patients with ischemia.

publication date

  • March 16, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000118465.36018.2D

PubMed ID

  • 14981004

Additional Document Info

start page

  • 1314

end page

  • 9

volume

  • 109

number

  • 10